Food Additive L-Theanine 98.5% CAS 3081-61-6

• CAS No.: 3081-61-6
• Formula: C7h14n2o3
• EINECS: 221-379-0
• Packaging Material: Plastic
• Storage Method: Normal
• Shelf Life: 24 Months
• Model NO.: 3081-61-6
• Nutrient Composition: Amino Acid
• Resource: Natural
• The content of active substances: 99%
• Quality Standard: FCC
• Transport Package: Carton, Drum
• Specification: 25Kg
• Origin: China
• HS Code: 2933290090
• Production Capacity: 10, 000, 000kg/Year

Product Description

Product Name               L-Theanine
Alias                               N-gamma-ethyl-L-glutamine
Molecular Formula        C₇H₁₄N₂O₃
Molecular Weight          174.1977
CAS No.                          3081-61-6
Shelf Life                       2 years  
Quality Standard           FCC

Specification:

ANALYTICAL ITEMS	SPECIFICATION
Appearance	White crystalline powder
Assay	98.0%~102.0%
Specific optical rotation[a]D^20°	+7.7^o~ +8.5^o
Solubility	Clear and colorless
pH	5.0~6.0
Loss on drying	≤1.0%
Residue on ignition	≤0.2%
Chloride (Cl)	≤0.02%
Heavy Metals	≤10PPm
Lead	≤1PPm
Arsenic	≤1PPm
Cadmium	≤1PPm
Mercury	≤0.1PPm
Total plate count	<1,000CFU/g
Mold & Yeast	<100CFU/g
Salmonella	Negative/10g
E.Coli	Negative/10g

Application:   

Antihypertensive effect

Blood pressure regulation is mainly achieved through the increase or decrease of catecholamine and serotonin in the central and peripheral nervous system. Yokogoshi et al. Proved through experiments that theanine can reduce the content of serotonin, reduce the synthesis of serotonin in the brain and increase its decomposition in the brain. When different doses of theanine were injected into spontaneously hypertensive rats (SHR), the blood pressure decreased, and the degree of decline showed a dose-response relationship. A significant decrease in blood pressure could be observed in the high-dose group; however, even the highest dose of theanine would not change the blood pressure of normal rats; similar to the structure of theanine, glutamate did not reduce blood pressure.

Adjuvant antitumor effect

Recent studies have shown that theanine itself has no antitumor activity, but it can improve the efficacy of a variety of antitumor drugs. Adriamycin (adriamycin cm) can inhibit some tumors. Theanine can protect the concentration of adriamycin in tumor tissues and reduce the exudation of adriamycin from Ehrlich ascites tumor cells. Therefore, when theanine is used with adriamycin, the inhibition of tumor growth in vivo can be increased by 2.1 times and the concentration of adriamycin in tumor tissues can be increased by 2.9 times. In addition, injection of the anticancer drug idarubicin can reduce the number of leukocytes and bone marrow cells, but when combined with theanine, it can alleviate the toxicity of idarubicin and promote the antitumor effect of idarubicin, indicating that theanine has a selective regulatory effect on the toxicity caused by idarubicin. Doxorubicin combined with theanine can inhibit the metastasis of M5076 ovarian sarcoma to the liver. Recently, SA dzuka et al. Further studied the pathway of theanine improving the anticancer activity of doxorubicin, pointing out that theanine increases the concentration of doxorubicin in tumor cells by inhibiting glutamate transmission in tumor cells, so as to improve its anticancer efficacy. Theanine is very beneficial to the clinical chemotherapy of cancer patients. It not only promotes the effect of some antitumor drugs, but also improves the quality of life of cancer patients.

Relax the nervous tension, relaxation, etc

Terashima et al. Found that the main receptor of theanine is brain. After theanine enters the brain through the brain barrier, the neurotransmitter dopamine in the midline of brain cells increases significantly. It is an important substance to convey the excitement of brain nerve cells. Its release will greatly affect people's mood. In addition, yokogoshi et al. Found that theanine can affect the synthesis and decomposition of serotonin in the brain by using serotonin (serotonin) metabolism inhibitors. After taking theanine, the content of tryptophan in the brain increased significantly or tended to increase, but the content of serotonin decreased. Theanine may reduce serotonin synthesis and increase its decomposition, or inhibit serotonin release.

Generally speaking, animals and people always produce very weak pulse impulses on the surface of the brain, called brain waves. Under different mental conditions, the brain will produce brain waves with different current frequencies. Brain waves are divided according to frequency α,β,δ and θ Wave, δ When Bo was sleeping, θ When the wave is in the ton state, α When the wave is quiet (relaxed state), β Waves appear separately in the excited state. Some people conducted human experiments to verify the effect of theanine on spirit, let the experimenters drink water and theanine aqueous solution, and measure EEG after 60min; Results EEG changes were found at the end of drinking water, but significant changes were observed after drinking theanine α Therefore, theanine can promote the generation of second wave, so as to cause a comfortable and pleasant feeling. And theanine did not cause sleep θ The number of waves increases, so theanine can not only stabilize people's mood, but also make people pay more attention.

Protective effect on brain nerve cells

Glutamate is an excitatory neurotransmitter, and its content in nerve cells is maintained at 1mmol-10mmol / L. During cerebral ischemia, due to the interruption of O2 supply, the intracellular energy substance adenosine triphosphate (ATP) production is reduced and gradually depleted. The nerve cell membrane is separated, too much glutamate is released outside the cell, and acts on the receptor to continuously increase the intracellular calcium concentration, stimulate the activities of various decomposition enzymes, and finally act on the cell to destroy and die. Theanine has a competitive protective effect on glutamate receptor, so theanine has a protective effect on brain tissue and can avoid brain nerve cell death caused by cerebral ischemia.

Improve menstrual syndrome

Menstrual syndrome (PMS) is a symptom of mental and physical discomfort in women 3 to 10 days before menstruation. Juneja et al. Investigated the effect of theanine on PMS and asked 24 women to take theanine 200mg every day. Two months later, PMS symptoms were significantly improved, such as headache, low back pain, chest pain, weakness, fatigue, inability to concentrate, irritability and so on. Its mechanism needs further study, which may be related to the sedative effect of theanine.

Weight loss effect

After fed with 0.028% theanine for 16 weeks, the weight of mice decreased significantly compared with the control group, and the abdominal fat decreased to 58% of the control group. At the same time, the contents of neutral fat and cholesterol in blood decreased by 32% and 15% respectively, and the cholesterol in liver decreased by 28%. Therefore, the weight loss effect of tea is the result of the joint action of various components in tea, including theanine. Theanine is especially effective in reducing cholesterol in the body.

Anti fatigue effect

After 30 days of oral administration of theanine to mice, the weight-bearing swimming experiment was used to observe and record the swimming death time of mice; After swimming for a certain time, blood samples were taken to detect serum urea nitrogen and blood lactic acid; The liver was taken to detect liver glycogen. Results oral administration of theanine at different doses for 30 days could significantly prolong the swimming time, reduce the consumption of liver glycogen and reduce the level of serum urea nitrogen during exercise; It can significantly inhibit the increase of blood lactic acid after exercise and promote the elimination of blood lactic acid after exercise. Therefore, theanine has anti fatigue effect. The mechanism may be related to that theanine can inhibit the secretion of s-hydroxytryptamine and promote the secretion of catecholamine (5-hydroxytryptamine has inhibitory effect on the central nervous system, while catecholamine has excitatory effect).


Packing: 
25kg/drum

Storage: 
Store in tightly closed original container, protected from light, in a dry place.